INDICATIONS: Treatment of severe infections of the urinary and gastrointestinal tracts including Campylobacter jejuni, Shigella or Salmonella; susceptible sexually transmitted diseases; e.g., gonococcal (including penicillin resistant) and non-gonococcal (chlamydial) urethritis; osteomy- elitis/septicemia caused by susceptible organisms including bacteria resistant to beta-lactams; severe infections of the respiratory tract due to susceptible gram-negative infections including Pseudomonas aeruginosa; treatment of multi-drug resistant tuberculosis in combination with other drugs; treatment of multi-drug resistant typhoid fever; post-expo- sure prophylaxis for meningococcal disease and anthrax in adults.
CONTRA-INDICATIONS Safety during pregnancy and lactation has not been established. Ciprofloxacin is contra-indicated in children under 18 years and in growing adolescents, except where the benefits of treatment exceed the risks. Experimental evidence indicates that, species variable, reversible lesions of the cartilage of weight bearing joints has been seen in immature members of certain animal species. Ciprofloxacin is contra-indicated in patients who have shown hypersensitivity to ciprofloxacin or anyother quinolones.
WARNINGS: Ciprofloxacin should be used with caution in patients with a history of convulsive disorders. Crystalluria related to the use of ciprofloxacin has been observed. Patients receiving ciprofloxacin should be well hydrated and excessive alkalinity of the urine should be avoided.
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